We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates. BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our ’learner’ discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the (...) relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system. (shrink)

Early versions of satellite and radiosonde datasets suggested that the tropical surface had warmed more than the troposphere, while climate models consistently showed tropospheric amplification of surface warming in response to human-caused increases in greenhouse gases. We revisit such comparisons here using new observational estimates of surface and tropospheric temperature changes. We find that there is no longer a serious discrepancy between modeled and observed trends in the tropics. Our results contradict a recent claim that all simulated temperature trends in (...) the tropical troposphere are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”.This emerging reconciliation of models and observations has two primary explanations. First, because of changes in the treatment of buoy and satellite information, new surface temperature datasets yield slightly reduced tropical warming relative to earlier versions. Second, recently developed satellite and radiosonde datasets now show larger warming of the tropical lower troposphere. In the case of a new satellite dataset from remote sensing systems, enhancedRSS warming is due to an improved procedure of adjusting for inter-satellite biases. When the RSS-derived tropospheric temperature trend is compared with four different observed estimates of surface temperature change, the surface warming is invariably amplified in the tropical troposphere, consistent with model results. Even if we use data from a second satellite dataset with smaller tropospheric warming than in remote sensing systems RSS, observed tropical lapse rates are not significantly different from those in all model simulations.Our results contradict a recent claim that all simulated temperature trends in the tropical troposphere and in tropical lapse rates are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”. (shrink)

A brief statement of medieval linguistic analysis as found chiefly in the works of Thomas Aquinas. A thin survey of contemporary analysis is offered in order to contrast the purported acceptance of analysis as the end of philosophy with Thomas' use of analysis as method. Unfortunately, most of the constructive work in language analysis during the past ten years is not considered. The brevity of the text precludes persuasive treatment; yet the book succeeds in its expressed purpose of sketching some (...) chief differences between the medieval and contemporary approaches in the hope that the confrontation of these currents will bring to the fore the analytic work of Aquinas himself.--D. P. B. (shrink)

A prosaic and unimaginative introductory textbook. The author claims that his aim is "not to introduce the student to the various philosophies but to introduce him to the kind of thinking from which philosophy comes." The very patness of his presentation, however, discourages original philosophical thinking.--D. P. B.

A new and idiomatic translation of the most important questions in the Summa Theologica pertaining to the nature of the human soul and human knowledge.--D. P. B.

Southern examines three phases in the development of the western view of Islam from 650 to 1570. In an historical study of these phases he traces the gradual emergence of a critical spirit of inquiry regarding Islam. The author argues that "... medieval scholars and men of affairs came up against problems with which, in a different context, we are familiar."--D. P. B.

Directed to the non-philosopher, this is an attempt to sketch briefly a public philosophy for contemporary America. It attacks the "enfeebling naturalism" of Dewey and espouses the right of suffrage as the most fundamental right of man.--D. P. B.

The major portion of the book is devoted to an extensive treatment of Bacon's political and legal career. Against this background, Anderson traces the emergence of Bacon's inductive method, from his rejection of Peripatetic principles in the Advancement of Learning to the triumph of the method with the Royal Society. The conspicuous absence of footnotes and bibliography detracts from this otherwise thorough and sympathetic study of Bacon.--D. P. B.

An introductory text which deals with several of the basic problems of semantical and logical analysis. Most of the discussion is devoted to problems of usage, rules, inference, and validity. A rather cumbersome symbolism results from the author's explicit attempt to treat these problems with the formal tools of elementary symbolic logic.--D. P. B.

This collection of Professor S. Sastri's work indicates the depth of his contribution to Indian philosophy. The reader will find his development of Bradley's Idealism in the light of the Advaita tradition to be of special philosophic interest.--D. P. B.

Essays by E. B. Allaire, May Brodbeck, Reinhart Grossmann, Herbert Hochberg and Robert G. Turnbull, most of which have already appeared since 1959. Half of the essays argue answers of a realist type to contemporary statements of traditional ontological problems. The second half of the volume studies the ontological "systems" of Ockhom, Berkeley, Frege, Moore, Wittgenstein, Quine and Dewey from a realistic standpoint. Three previously unpublished essays are included: "Particulars and Time", "Common Names", and "The 'Tractatus': Nominalistic or Realistic?". An (...) excellent beginning for a promising series.--D. P. B. (shrink)

The author sees Parsifal as setting the essential problem for the present age. From a study of the grail myths, Spieler attempts to point the way to a synoptic view of experience. Basic to the project is his view that everything is a product of the logos which permeates all of reality. It is by virtue of the logical law, as the causal nexus of experience, that a reconciliation of fragmented experience is seen to be possible. A carefully documented and (...) interesting study.--D. P. B. (shrink)

Background: Concern has been expressed about the process of consent to clinical trials, particularly in phase I “first-in-man” trials. Trial participant information sheets are often lengthy and technical. Content-based readability testing of sheets, which is often required to obtain research ethics approval for trials in the USA, is limited and cannot indicate how information will perform. Methods: An independent-groups design was used to study the user-testing performance of the participant information sheet from the phase I TGN1412 trial. Members of the (...) public were asked to read it, then find and demonstrate understanding of 21 key aspects of the trial. The participant information sheet was then rewritten, redesigned and tested on 20 members of the public, using the same 21-item questionnaire. Results: On the original TGN1412 participant information sheet, participants could not find answers and some of the found information was not understood. Six of 21 questions, including those relating to placebo, follow-up visits and the emergency phone number, were found by eight or fewer of 10 participants. The revised information sheet performed better, with the answers to 17 of 21 questions found and understood by all 20 participants. Conclusions: Tests showed that the TGN1412 participant information sheet may not inform participants adequately for consent. Revising its content and design led to significant improvements. Writers of materials for trial participants should take account of good practice in information design. Performance-based user testing may be a useful method to indicate strengths and weaknesses in trial materials. (shrink)

First published in 1972, The Hope of Progress presents collection of essays and lectures dealing with the history of scientific ideas and the impact of science on society. The principle piece in this volume is the author's 1969 presidential address to the British Association 'On The Effecting of All Things Possible', an argument for believing in the ability of science to solve the problems it has itself created, and which too many of us believe insoluble. It contains author's Romanes Lecture (...) on 'Science and Literature' and a well known critique of J.D. Watson's notorious account of the discovery of the molecular structure of DNA, The Double Helix. Other chapters discuss the possibility of the control and domination by science of the body and mind of Man- though the author concludes in 'The Genetic Improvement of Man' 'I think that, in the main, for many centuries to come, we shall have to put up with human beings as they are at present constituted'. This book will be useful for scholars and researchers of history of science, philosophy of science, natural science, and philosophy in general. (shrink)

Background: Debates over legalisation of physician-assisted suicide or euthanasia often warn of a “slippery slope”, predicting abuse of people in vulnerable groups. To assess this concern, the authors examined data from Oregon and the Netherlands, the two principal jurisdictions in which physician-assisted dying is legal and data have been collected over a substantial period.Methods: The data from Oregon comprised all annual and cumulative Department of Human Services reports 1998–2006 and three independent studies; the data from the Netherlands comprised all four (...) government-commissioned nationwide studies of end-of-life decision making and specialised studies. Evidence of any disproportionate impact on 10 groups of potentially vulnerable patients was sought.Results: Rates of assisted dying in Oregon and in the Netherlands showed no evidence of heightened risk for the elderly, women, the uninsured , people with low educational status, the poor, the physically disabled or chronically ill, minors, people with psychiatric illnesses including depression, or racial or ethnic minorities, compared with background populations. The only group with a heightened risk was people with AIDS. While extralegal cases were not the focus of this study, none have been uncovered in Oregon; among extralegal cases in the Netherlands, there was no evidence of higher rates in vulnerable groups.Conclusions: Where assisted dying is already legal, there is no current evidence for the claim that legalised PAS or euthanasia will have disproportionate impact on patients in vulnerable groups. Those who received physician-assisted dying in the jurisdictions studied appeared to enjoy comparative social, economic, educational, professional and other privileges. (shrink)

Aim: Patients with advanced cancer need information about end-of-life treatment options in order to make informed decisions. Clinicians vary in the frequency with which they initiate these discussions.Patients and methods: As part of a long-term longitudinal study, patients with an expected 2-year survival of less than 50% who had advanced gastrointestinal or lung cancer or amyotrophic lateral sclerosis were interviewed. Each patient’s medical record was reviewed at enrollment and at 3 months for evidence of the discussion of patient wishes concerning (...) ventilator support, artificial nutrition and hydration , resuscitation and hospice care. A Kaplan–Meier analysis was also performed and 2-year survival calculated.Results: 60 cancer and 32 ALS patients were enrolled. ALS patients were more likely than cancer patients to have evidence of discussion about their wishes for ventilator support , ANH , DNR and hospice care . At 6 months, 91% of ALS patients were alive compared with 62% of cancer patients; at 2 years, 63% of ALS patients were alive compared with 23% of cancer patients .Conclusions: Cancer patients were less likely than ALS patients to have had documented advanced care planning discussions despite worse survival. This may reflect perceptions that ALS has a more predictable course, that advanced cancer has a greater number of treatment options, or differing views about hope. Nevertheless, cancer patients may be less adequately prepared for end-of-life decision-making. (shrink)